Capsaicin, the active ingredient in spicy chili peppers, is more than just a culinary ingredient that adds heat to your dishes. This potent compound has been making waves in the medical community for its potential to manage chronic pain12. By the end of this article, you’ll understand how utilize Capsaicin for Pain relief and where to find top rated products to try out!
How Capsiacin for Pain Relief Works

Capsaicin works by interacting with our body’s pain pathways. It binds to a receptor called TRPV1, which is present in pain-sensing nerve cells. When capsaicin binds to TRPV1, it triggers these cells to release Substance P, which transmits pain signals to the brain. However, continuous application of capsaicin depletes Substance P, ultimately reducing the pain signals sent to the brain, leading to pain relief1.
The Clinical Efficacy of Capsaicin for Pain
Capsaicin’s effectiveness in managing various types of chronic pain, including neuropathic pain and musculoskeletal pain, is well-documented in medical literature1. Moreover, a high-concentration capsaicin 8% patch has shown effective pain management, providing targeted, localized pain relief with minimal side effects2.
The Therapeutic Potential of Capsaicin
Capsaicin’s role in pain relief is one of its many therapeutic properties. It also has potential benefits in treating various health conditions, including metabolic syndrome and cancer3.
Types of Pain Capsaicin Helps

Capsaicin has shown promise in managing various types of pain:
- Neuropathic Pain: Conditions like postherpetic neuralgia and diabetic neuropathy can cause this pain. A high-concentration capsaicin 8% patch has shown effectiveness in managing neuropathic pain4.
- Musculoskeletal Pain: Conditions such as osteoarthritis and fibromyalgia fall under this category. Capsaicin can help manage the pain associated with these conditions by desensitizing pain receptors4.
- Post-Surgical Pain: Pain following surgery can be managed effectively with capsaicin, providing a non-opioid option for pain management4.
- Visceral Pain: Conditions like irritable bowel syndrome (IBS) cause this type of pain. Capsaicin’s ability to desensitize pain receptors can help manage the pain associated with these conditions4.
Additional Benefits of Capsaicin
Beyond its potent pain-relieving properties, capsaicin comes with several other health benefits:
- Management of Osteoarthritis: Capsaicin may help manage osteoarthritis, a degenerative joint disease. It effectively reduces pain and improves function in patients with hand, hip, and knee osteoarthritis5.
- Promotion of Metabolic Health: Interestingly, capsaicin and other short-chain fatty acids, generated by gut microbiota, have been found to promote metabolic benefits. They are associated with improved body weight and glucose control, partly through the activation of intestinal gluconeogenesis6
- Potential Anti-Cancer Properties: Some research suggests capsaicin may have potential anti-cancer properties. Research is ongoing to confirm and to understand this potential benefit7 fully.
Top-Rated Capsaicin Products

Here are some of the top-rated capsaicin pain relief products available on Amazon:
- MT Healthy 20 Pcs Capsicum Plaster Capsaicin Patch for Pain Relief: This large patch relieves arthralgia, back pain, and stiff shoulder and muscular pain.
- Globe (3 Pack) Capsaicin 0.1% High Potency Pain Relief Cream, Unscented: This high-potency cream offers deep penetrating relief from arthritis, muscle, joint, and back pain.
- 24-Count Pain Relief Patches: These patches provide long-lasting relief for joint pains and have a maximum strength warming herbal plaster.
- CapsaicinGinger Pain Relief Patches: These hot capsicum patches help relieve pain in areas like the wrist, back, and knee joints.
- Pure Body Naturals Max Strength Hot Cream: This natural muscle pain relief cream helps relieve sore muscles, arthritis, sports injuries, chronic pain, and inflammation.
Precautions When Using Capsaicin for Pain
While capsaicin is a natural and effective pain reliever, it’s essential to consider the following precautions before using it:
- Skin Irritation: Capsaicin can cause a burning sensation or skin irritation when first applied. Skin irritation usually decreases over time with continued use. If the burning sensation is too intense or you experience severe redness or swelling, discontinue use and consult a healthcare provider.
- Avoid Contact with Eyes and Mucous Membranes: Capsaicin can cause severe burning and irritation if it makes contact with the eyes, mouth, or other mucous membranes. Always wash your hands thoroughly after applying capsaicin cream or handling capsaicin patches.
- Allergies: Some people may be allergic to capsaicin. If you experience itching, swelling, severe redness, or difficulty breathing after using capsaicin, seek medical help immediately.
Conclusion
Capsaicin, a natural compound found in chili peppers, offers a promising, natural approach to managing chronic pain. Its unique mechanism of action and therapeutic potential make it a valuable tool in pain management.
Capsaicin for pain relief is a growing field of study, and ongoing research continues to uncover its potential. The next time you feel the heat from chili pepper, remember – it’s not just about the spice; it’s also about the potential relief it could bring to those suffering from chronic pain.
As always, it’s recommended to speak with a doctor or healthcare team before starting any new treatment regimen involving capsaicin, or any other supplement or routine.
More Stories
Find more amazing stories on the blog!
References:
- Anand, P., & Bley, K. (2011). Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. British Journal of Anaesthesia, 107(4), 490–502. https://doi.org/10.2147/JPR.S17490
- Bode, A. M., & Dong, Z. (2011). The two faces of capsaicin. Cancer Research, 71(8), 2809–2814. https://doi.org/10.1155/2014/203860
- Woolf, C. J. (2011). Central sensitization: Implications for the diagnosis and treatment of pain. Pain, 152(3 Suppl), S2–15. https://doi.org/10.1016/j.pain.2010.09.030
- McCormack, P. L. (2014). Capsaicin dermal patch: in non-diabetic peripheral neuropathic pain. Drugs, 74(12), 1375–1382. https://doi.org/10.1007/s40263-019-00655
- Hochberg, M. C., et al. (2012). American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care & Research, 64(4), 465–474. https://doi.org/10.1002/acr.21596
- Zhang, W., et al. (2005). EULAR evidence based recommendations for the management of hand osteoarthritis: Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Annals of the Rheumatic Diseases, 64(5), 669–681. https://doi.org/10.1136/ard.2006.062091
- De Vadder, F., et al. Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits. Cell, 156(1-2), 84–96. https://doi.org/10.1016/j.cell.2013.12.016